–11.7% reduction in wrinkle depth in the “crow’s feet” area*
–11.7%
over 84 days
*Based on an 84-day clinical study of the full 7-product INSTYTUTUM AM/PM routine among 21 women aged 35–60.
Clinically tested
−3 years in calculated skin biological age on average, in 3 months*
Before / Initial Condition
After / 84 days
Biological skin age is not the same as chronological age; it is a measurable condition of the skin
In a study of the INSTYTUTUM comprehensive skincare routine, the calculated skin's biological age decreased by 3 years as measured by the depth of periorbital wrinkles*
–3 years
in 3 months*
A measured reduction in the calculated skin's biological age over 84 days.
*Based on an 84-day clinical study of the full 7-product INSTYTUTUM AM/PM routine among 21 women aged 35–60. The claimed reduction in “skin biological age” is a calculated age equivalent based solely on periocular (crow’s feet) wrinkle depth measurement and does not constitute a medical or comprehensive assessment of biological age. Individual results may vary.
100% of participants noted visible results and comfort from the routine*
100% — improved hydration
100% — smoother skin and a more even texture
100% — enhanced radiance
100% — daily skin comfort
100% — full adherence to all steps of the routine
100% — comfort and tolerability of the Eye Cream
100% — improved skin tone and texture with the Glow Toner
94.9% — average percentage of positive ratings for additional results*
95,2% — improvement in elasticity
95,2% — radiance and even skin tone with Vitamin C Serum
95,2% — effectiveness and tolerability of Retinol Serum
95,2% — restoration and comfort with Superbiotic Cream
93,6% — willingness to continue using the routine on average throughout the study
*Based on the participants’ assessments of changes in skin condition on day 84 and the average values for days 28, 56, and 84 of the study “Clinical and Instrumental Evaluation of the Effectiveness of the INSTYTUTUM Skincare Routine.”
Longevity Skincare, designed to reduce the skin's biological age*
INSTYTUTUM's Comprehensive Routine: 7 products. 8 steps. 84 days. Clinically proven results.
Methodology of the Study
Clinical and Instrumental Assessment of the Effectiveness of the INSTYTUTUM Skincare Routine*
Efficacy Endpoints:
Depth of wrinkles in the “crow’s feet” area
Estimated biological age of the skin
Elasticity R2
Skin deformability R0
Standardized digital photographic documentation
Participants’ assessment of changes in skin condition
*Based on an 84-day open-label clinical-instrumental study conducted under the supervision of a dermatologist at an independent European laboratory evaluating the full 7-product INSTYTUTUM AM/PM skincare routine (Adaptogel Cleanser, Resurfacing Glow Toner, Brightening Vitamin C Serum, X-Strength Retinol Serum, Sunscription Dark Spot Defence SPF50, Superbiotic Regenerating Cream, and Transforming Brightening Eye Cream, each applied as directed) among 21 female participants aged 35–60 (skin phototypes I–IV) with visible signs of chrono- and/or photo-ageing. The claimed reduction in calculated skin biological age reflects an average age equivalent derived solely from 3D profilometry measurements of periocular (crow’s feet) wrinkle depth compared to the testing laboratory’s reference correlation database for women aged 30–65. This constitutes an aesthetic calculation based on a single parameter, not a medical, biological, or comprehensive assessment of overall skin or bodily ageing. Individual results may vary; in the study, not all participants showed a reduction in periocular wrinkle depth. “Longevity Skincare” describes the product category and formulation approach of the INSTYTUTUM range and is not a claim of any effect on lifespan, cellular ageing, or physiological ageing processes. Full study documentation is available for regulatory authorities upon request. Individual results may vary. The photos are without any retouching. All results are from actual product use.
84 days
of daily use of a comprehensive routine
21 participants
women aged 35–60
4 checkpoints
at the start, and after 28, 56, and 84 days
-11,7%
reduction in wrinkle depth in the “crow's feet” area*
+9%
skin elasticity R2*
-16,2%
skin deformability R0*
100%
participants noticed an improvement in skin smoothness and texture*
The effect intensifies over time*
Each checkpoint in the study confirmed further improvement in key markers of skin youthfulness
+9% elasticity, -16.2% skin deformability*
Elasticity R2
Firmness R0
*Based on an 84-day open-label clinical-instrumental study conducted under the supervision of a dermatologist at an independent European laboratory evaluating the full 7-product INSTYTUTUM AM/PM skincare routine (Adaptogel Cleanser, Resurfacing Glow Toner, Brightening Vitamin C Serum, X-Strength Retinol Serum, Sunscription Dark Spot Defence SPF50, Superbiotic Regenerating Cream, and Transforming Brightening Eye Cream, each applied as directed) among 21 female participants aged 35–60 (skin phototypes I–IV) with visible signs of chrono- and/or photo-ageing. The claimed reduction in calculated skin biological age reflects an average age equivalent derived solely from 3D profilometry measurements of periocular (crow’s feet) wrinkle depth compared to the testing laboratory’s reference correlation database for women aged 30–65. This constitutes an aesthetic calculation based on a single parameter, not a medical, biological, or comprehensive assessment of overall skin or bodily ageing. Individual results may vary; in the study, not all participants showed a reduction in periocular wrinkle depth. “Longevity Skincare” describes the product category and formulation approach of the INSTYTUTUM range and is not a claim of any effect on lifespan, cellular ageing, or physiological ageing processes. Full study documentation is available for regulatory authorities upon request. Individual results may vary. The photos are without any retouching. All results are from actual product use.